Main

Fields of interest:

• Ion channels
• Cardiac myocytes
• Calcium signaling
• Excitation - contraction coupling

Recent publications:

I. Zahradnik, I. Minarovic and A. Zahradnikova:
Inhibition of the cardiac L-type calcium channel current by antidepressant drugs,
J. Pharmacol. Exp. Ther., Vol. 324, (2008), pp. 977-984.

A. Zahradnikova, I. Minarovic and I. Zahradnik:
Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists,
J. Pharmacol. Exp. Ther., Vol. 322, (2007), pp. 638-645.

A. Zahradníková Jr, E. Poláková, I. Zahradník and A. Zahradníková:
Kinetics of calcium spikes in rat cardiac myocytes,
J. Physiol., Vol. 578, (2007), pp. 677-691.

I. Valent, A. Zahradníková, J. Pavelková and I. Zahradník:
Spatial and temporal Ca2+, Mg2+, and ATP2- dynamics in cardiac dyads during calcium release,
Biochim. Biophys. Acta, Vol. 1768, (2007), pp. 155-166.

N. Pourmand, M. Karhánek, H.H. Persson, C.D. Webb, T.H. Lee, A. Zahradníková and R.W. Davis:
Direct electrical detection of DNA synthesis,
Proc. Natl. Acad. Sci. USA, Vol. 103, (2006), pp. 6466-6470.

I. Zahradník, S. Györke and A. Zahradníková:
Calcium activation of ryanodine receptor channels – reconciling RyR gating models with tetrameric channel structure,
J. Gen. Physiol., Vol. 126, (2005), pp. 515-527.

A. Zahradníková, A. Kubalová, J. Pavelková, S. Györke and I. Zahradník:
Activation of calcium release assessed by calcium release-induced inactivation of calcium current in rat cardiac myocytes,
Am. J. Physiol. Cell Physiol., Vol. 286, (2004), pp. C330-C341.

A. Zahradníková, M. Dura, I. Györke, A.L. Escobar, I. Zahradník and S. Györke:
Regulation of dynamic behavior of cardiac ryanodine receptor by Mg2+ under simulated physiological conditions,
Am. J. Physiol. Cell Physiol., Vol. 285, (2003), pp. C1059-C1070.

A. Zahradníková, I. Zahradník, I. Györke and S. Györke:
Rapid activation of the cardiac ryanodine receptor by submillisecond calcium stimuli,
J. Gen. Physiol., Vol. 114, (1999), pp. 787-798.

L.G. Mészáros, A. Zahradníková and P. Volpe:
Kinetic basis of quantal calcium release from intracellular calcium stores,
Cell Calcium, Vol. 23, (1998), pp. 43-52.