Main

Fields of interest:

• Apoptosis
• DNA damage and repair
• Carcinogenesis
• Nucleo-cytoplasmic trafficking
• Uracil-DNA, thymine-less cell death
• Structural biology
• Enzymatic mechanisms

Recent publications:

J. Kovári, O. Barabás, B. Varga, A. Békési, F. Tölgyesi, J. Fidy, J. Nagy and B.G. Vértessy:
Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site,
Proteins, (2007); [Epub ahead of print].

J. Tóth, B. Varga, M. Kovács, A. Málnási-Csizmadia and B.G. Vértessy:
Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme,
J. Biol. Chem., Vol. 282, (2007), pp. 33572-33582.

B. Varga, O. Barabás, J. Kovári, J. Tóth, E. Hunyadi-Gulyás, E. Klement, K.F. Medzihradszky, F. Tölgyesi, J. Fidy and B.G. Vértessy:
Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase,
FEBS Lett., Vol. 581, (2007), pp.4783-4788.

A. Békési, M. Pukáncsik, V. Muha, I. Zagyva, I. Leveles, E. Hunyadi-Gulyás, E. Klement, K.F. Medzihradszky, Z. Kele, A. Erdei, F. Felföldi, E. Kónya and B.G. Vértessy:
A novel fruitfly protein under developmental control degrades uracil-DNA,
Biochem. Biophys. Res. Commun., Vol. 355, (2007), pp. 643-648.

V. Nemeth-Pongracz, O. Barabas, M. Fuxreiter, I. Simon, I. Pichova, M. Rumlova, H. Zabranska, D. Svergun, M. Petoukhov, V. Harmat, E. Klement, E. Hunyadi-Gulyas, K.F. Medzihradszky, E. Konya and B.G. Vertessy:
Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins,
Nucleic Acids Res., Vol. 35, (2007), pp. 495-505.

S.U. Lari, C.Y. Chen, B.G. Vertessy, J. Morre and S.E. Bennett:
Quantitative determination of uracil residues in Escherichia coli DNA: Contribution of ung, dug, and dut genes to uracil avoidance,
DNA Repair (Amst), 2006, Vol. 5, pp. 1407-1420.

O. Barabas, V. Nemeth and B.G. Vertessy:
Crystallization and preliminary X-ray studies of dUTPase from Mason-Pfizer monkey retrovirus,
Acta Crystallograph Sect. F Struct Biol Cryst Commun., Vol. 62, (2006), pp. 399-401.

O. Barabas, V. Pongracz, J. Kovari, M. Wilmanns and B.G. Vertessy:
Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase,
J. Biol. Chem., Vol. 279, (2004), pp. 42907-42915.

E. Takacs, V.K. Grolmusz and B.G. Vertessy:
A tradeoff between protein stability and conformational mobility in homotrimeric dUTPases,
FEBS Lett., Vol. 566, (2004), pp. 48-54.

A. Bekesi, I. Zagyva, E. Hunyadi-Gulyas, V. Pongracz, J. Kovari, A.O. Nagy, A. Erdei, K.F. Medzihradszky and B.G. Vertessy:
Developmental regulation of dUTPase in Drosophila melanogaster,
J. Biol. Chem., Vol. 279, (2004), pp. 22362-22370.