Main

Fields of interest:

• Physiologically active polymers and their use as drug carriers, slow release systems
• Engineering of arious systems for controlled delivery of pharmaceuticals
• Targeted delivery of therapeutic and diagnostic agents
• Physico-chemical aspects of enzyme stabilization and immobilization on polymeric carriers, therapeutic enzymes
• Artificial phospholipid membranes, liposomes
• Micellar solubilization of poorly soluble drugs
• Experimental diagnostic imaging
• Experimental tumor immunology and therapy

Recent publications:

V.P.Torchilin,
Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate,
Adv. Drug Deliv. Rev., 57, 95-109, 2005.

V.P.Torchilin,
Recent advances with liposomes as pharmaceutical carriers,
Nature Rev. Drug Discov., 4, 145-160, 2005.

B.Gupta, T.Levchenko, V.P.Torchilin,
Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides,
Adv. Drug Deliv. Rev., 57, 637-651, 2005.

V.P.Torchilin,
Recent approaches to intracellular delivery of drugs and DNA and organelle targeting,
Ann. Rev. Biomed. Eng., 8, 343-375, 2006.

B.Gupta, V.P.Torchilin,
TAT peptide-modified liposomes provide enhanced gene delivery to intracranial human brain tumor xenografts in nude mice,
Oncol. Res., 16, 351-359, 2007.

S.Erdogan, Z.O.Medarova, A.Roby, A.Moore, V.P.Torchilin,
Enhanced tumor MR imaging with Gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes,
J. Magn. Res. Imaging., 27, 574-580, 2008.

Y.T.Ko, W.C.Hartner, A.Kale, V.P.Torchilin,
Gene delivery into ischemic myocardium by double-targeted lipoplexes with anti-myosin antibody and TAT peptide,
Gene Therapy, 16, 52-59, 2009.

Y.T.Ko, A.Kale, W.C.Hartner, B.Papahadjopoulos-Sternberg, V.P.Torchilin,
Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery.
J. Control. Release, 133, 132-138, 2009.

T.A.ElBayoumi, V.P.Torchilin,
Tumor-targeted nanomedicines: enhanced antitumor efficacy in vivo of doxorubicin-loaded, long-circulating liposomes modified with cancer-specific monoclonal antibody,
Clin. Cancer Res., 15, 1973-1980, 2009.

T.Wang, G.G.D'Souza, D.Bedi, O.A.Fagbohun, L.P.Potturi, B.Papahadjopoulos-Sternberg, V.A.Petrenko, V.P.Torchilin,
Enhanced binding and killing of target tumor cells by drug-loaded liposomes modified with tumor-specific phage fusion coat protein,
Nanomedicine (Lond), 5, 563-574, 2010.