Main

Fields of interest:

• Enzymology
• Enzyme kinetics
• Protein tyrosine phosphatases
• Structural biology

Recent publications:

L. Tabernero, A.R. Aricescu, E.Y. Jones and S.E. Szedlacsek:
Protein tyrosine phosphatases: structure-function relationships,
FEBS J., Vol. 275, (2008), pp. 867–882.

M. Köhn, M. Gutierrez-Rodriguez, P. Jonkheijm, S. Wetzel, R. Wacker, H. Schroeder, H. Prinz, C.M. Niemeyer, R. Breinbauer, S.E. Szedlacsek and H. Waldmann:
A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatas,
Angew. Chem. Int. Ed. Engl., Vol. 46, (2007), pp. 7700-7703.

M.O. Vlad, F. Morán, V.T. Popa, S.E. Szedlacsek and J. Ross:
Functional, fractal nonlinear response with application to rate processes with memory, allometry, and population genetics,
Proc. Natl. Acad. Sci. USA, Vol. 104, (2007), pp. 4798-4803.

B. Dursina, R. Reents, C. Delon, Y. Wu, M. Kulharia, M. Thutewohl, A. Veligodsky, A. Kalinin, V. Evstifeev, D. Ciobanu, S.E. Szedlacsek, H. Waldmann, R.S. Goody and K. Alexandrov:
Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids,
J. Am. Chem. Soc., Vol. 128,=(2006), pp. 2822-2835.

M.O. Vlad, S.E. Szedlacsek, N. Pourmand, L.L. Cavalli-Sforza, P. Oefner and J. Ross:
Fisher's theorems for multivariable, time- and space-dependent systems, with applications in population genetics and chemical kinetics,
Proc. Natl. Acad. Sci. USA, Vol. 102, (2005), pp. 9848-9853.

V.B. Cismasiu, S.A. Denes, H. Reilander, H. Michel and S.E. Szedlacsek:
The MAM (meprin/A5-protein/PTPmu) domain is a homophilic binding site promoting the lateral dimerization of receptor-like protein-tyrosine phosphatase mu,
J. Biol. Chem., Vol. 279, (2004), pp. 26922-26931.

A.R. Aricescu, T.A. Fulga, V. Cismasiu, R.S. Goody and S.E. Szedlacsek:
Intramolecular interactions in protein tyrosine phosphatase RPTPmu: kinetic evidence,
Biochem. Biophys. Res. Commun., Vol. 280, (2001), pp. 319-327.

S.E. Szedlacsek, A.R. Aricescu, T.A. Fulga, L. Renault and A.J. Scheidig:
Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation,
J. Mol. Biol., Vol. 311, (2001), pp. 557-568.

A. Baici, S.E. Szedlacsek, H. Fruh and B.A. Michel:
pH-dependent hysteretic behaviour of human myeloblastin (leucocyte proteinase 3),
Biochem. J., Vol. 317 (Pt 3), (1996), pp. 901-905.

S.E. Szedlacsek, A.R. Aricescu and B.H. Havsteen:
Time-dependent control of metabolic systems by external effectors,
J. Theor. Biol., Vol. 182, (1996), pp. 341-50.