Main

Fields of interest:

• hematooncology and experimental oncology
• pharmacogenomics
• general immunology

Recent publications:

M. Nieborowska-Skorska, P.K. Kopinski, R. Ray, G. Hoser, D. Ngaba, S. Flis, K. Cramer, M.R. Reddy, M. Koptyra, T. Penserga, E. Glodkowska-Mrowka, E. Bolton, T.L. Holyoake, C.J. Eaves, S. Cerny-Reiterer, P. Valent, A. Hochhaus, T.P. Hughes, H. van der Kuip, M. Sattler, W. Wiktor-Jedrzejczak, C. Richardson, A. Dorrance, T. Stoklosa, D.A. Williams, T. Skorski:
Rac2-mitochondrial respiratory chain complex III-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors,
Blood, (2012), Mar 12. [Epub ahead of print]

A.  Virgili, M. Koptyra, Y. Dasgupta, E. Glodkowska-Mrowka, T. Stoklosa, E.P. Nacheva, T. Skorski:
Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele,
Cancer Res, Vol.71(16), (2011), pp.5381-6.

M. Koptyra, T. Stoklosa, G. Hoser, E. Glodkowska-Mrowka, I. Seferynska, A. Klejman, J. Blasiak, T. Skorski:
Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis,
Leukemia,Vol.25(8), (2011), pp.1259-67.

A. Szokalska, M. Makowski, D. Nowis, G.M. Wilczynski, M. Kujawa, C. Wójcik, I. Mlynarczuk-Bialy, P. Salwa, J. Bil, S. Janowska, P. Agostinis, T. Verfaillie, M. Bugajski, J. Gietka, T. Issat, E. Glodkowska, P. Mrówka, T. Stoklosa, M.R. Hamblin, P. Mróz, M. Jakóbisiak, J. Golab:
Proteasome inhibition potentiates antitumor effects of photodynamic therapy in mice through induction of endoplasmic reticulum stress and unfolded protein response,
Cancer Res,Vol.69(10), (2009), pp.4235-43.

T. Stoklosa, T. Poplawski, M. Koptyra, M. Nieborowska-Skorska, G. Basak, A. Slupianek, M. Rayevskaya, I. Seferynska, L. Herrera, J. Blasiak, T. Skorski:
BCR/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations,
Cancer Res,Vol.68(8), (2008), pp.2576-80.

D. Nowis, M. Bugajski, M. Winiarska, J. Bil, A. Szokalska, P. Salwa, T. Issat, H. Was, A. Jozkowicz, J. Dulak, T. Stoklosa, J. Golab:
Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice,
BMC Cancer, Vol.8, (2008), pp.197.

M. Winiarska, J. Bil, E. Wilczek, G.M. Wilczynski, M. Lekka, P.J. Engelberts, W.J. Mackus, E. Gorska, L. Bojarski, T. Stoklosa, D. Nowis, Z. Kurzaj, M. Makowski, E. Glodkowska, T. Issat, P. Mrowka, W. Lasek, A. Dabrowska-Iwanicka, G.W. Basak, M. Wasik, K. Warzocha, M. Sinski, Z. Gaciong, M. Jakobisiak, P.W. Parren, J. Golab:
Statins impair antitumor effects of rituximab by inducing conformational changes of CD20,
PLoS Med, Vol.5(3), (2008), pp.e64.

L. Rink, A. Slupianek, T. Stoklosa, M. Nieborowska-Skorska, K. Urbanska, K. Reiss,I.Seferynska, T. Skorski:
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex RAD50-Mre11-Nbs1, can be targeted simultaneously with BCR/ABL kinase to eliminate leukemia cells,
Blood, Vol.110(2), (2007), pp.651-660. 

M. Koptyra, R. Falinski, M.O. Nowicki, T. Stoklosa, I. Majsterek, M. Nieborowska-Skorska, J. Blasiak, T. Skorski:
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance,
Blood, Vol.108, (2006), pp.319-327.

T. Stoklosa, A. Slupianek, M. Datta, M. Nieborowska-Skorska, M.O. Nowicki, M. Koptyra, T. Skorski:
BCR/ABL recruits p53 tumor suppressor protein to induce drug resistance,
Cell Cycle, Vol.3(11), (2004), pp.1463-1472.