Main

Fields of interest:

• Proteomics
• Cancer
• Breast cancer
• Systems biology
• Transforming growth factor-beta signalling

Recent publications:

H. Iwahana, I. Yakymovych, A. Dubrovska, U. Hellman, S. Souchelnytskyi:
Glycoproteome profiling of TGFbeta signalling: non-glycosylated CIDE-A inhibits TGFbeta1-dependent apoptosis,
Proteomics, (2006), in press.

Y. Wallez, F. Cand, F. Cruzalegui, C. Wernstedt, S. Souchelnytskyi, I. Vilgrain, P. Huber:
Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site,
Oncogene, (2006), doi: 10.1038/sj.onc.1209855.

T. Stasyk, A. Dubrovska, M. Lomnytska, C. Wernstedt, C.-H. Heldin, U. Hellman, S. Souchelnytskyi:
Phosphoproteome profiling of transforming growth factor-beta signalling: abrogation of TGFbeta1-dependent phosphorylation of TFII-I enhances cooperation of TFII-I and Smad3 in transcription,
Mol. Biol. Cell, Vol. 16, (2005), pp. 4765-4780.

A. Dubrovska, S. Souchelnytskyi:
Efficient enrichment for phosphorylated proteins by immobilized metal-affinity chromatography,
Proteomics, Vol. 5, (2005), pp. 4678-4683.

A. Dubrovska, T. Kanamoto, M. Lomnytska, C.-H. Heldin, N. Volodko, S. Souchelnytskyi:
TGFbeta/Smad3 counteracts BRCA1-dependent repair of DNA damage,
Oncogene, Vol. 21, (2005), pp. 2289-2297.

I. Yakymovych, C-H. Heldin, S. Souchelnytskyi:
Smad2 phosphorylation by type I receptor: contribution of arginine 462 and cysteine 463 in the C-terminus of Smad2 for specificity,
J. Biol. Chem., Vol. 279, (2004), pp. 35781-35787.

S. Grimsby, H. Jaensson, A. Dubrovska, M. Lomnytska, U. Helman, S. Souchelnytskyi:
Identification of proteins associated with Smad3: SREBP2 forms complex with Smad3 and inhibits its transcriptional activity,
FEBS Letters, Vol. 77, (2004), pp. 93-100.

S .Hassel, A. Eichner, M. Yakymovych, U. Hellman, P. Knaus, S. Souchelnytskyi:
Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry,
Proteomics, Vol. 4, (2004), pp. 1346-1358.

M. Lomnytska, V. Lukiyanchuk, U. Hellman, S. Souchelnytskyi:
TGFbeta1-regulated proteins in human endothelial cells identified by two-dimensional gel electrophoresis and mass spectrometry,
Proteomics, Vol. 4, (2004), pp. 995-1006.

T. Sjöblom, I. Yakymovych, C-H. Heldin, A. Östman, S. Souchelnytskyi:
Smad2 suppresses growth of Mv1Lu cells subcutaneously inoculated in mice,
Eur. J. Cancer, Vol. 40, (2004), pp. 267-274.

S. Souchelnytskyi:
Proteomics of TGFbeta signalling and its impact on breast cancer,
Expert Rev. Proteomics, Vol. 2, (2005), pp. 925-935.