Main

Fields of interest:

• Molecular and Structural Biology
• Biochemistry
• Mechanisms of gene expression regulation
• Nucleic acid-ligand interactions
• Nucleic acid and protein structure and catalysis

Recent publications:

L. Huang, S. Ishibe-Murakami, D.J. Patel, A. Serganov:
Long-range pseudoknot interactions dictate the regulatory response in the tetrahydrofolate riboswitch,
Proc. Natl. Acad. Sci. USA,Vol.108, (2011), pp.14801-14806.

O. Pikovskaya, A. Polonskaya, D.J. Patel, A. Serganov:
Structural principles of nucleoside selectivity in a 2'-deoxyguanosine riboswitch,
Nat. Chem. Biol., Vol.7, (2011), pp.748-755

A.T. Phan, V. Kuryavyi, J.C. Darnell, A. Serganov, A. Majumdar, S. Ilin, T. Raslin, A. Polonskaia, C. Chen, D. Clain, R.B. Darnell, D.J. Patel:
Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction,
Nat. Struct. Mol. Biol., Vol.18, (2011), pp.774-804.

A. Serganov:
Determination of riboswitch structures: light at the end of the tunnel?
RNA Biol., Vol.7, (2010), pp.98-103.

L. Huang, A. Serganov, D.J. Patel:
Structural insights into ligand recognition by a sensing domain of the cooperative glycine riboswitch,
Mol. Cell, Vol.40, (2010), pp.774-786.

A. Serganov:
The long and the short of riboswitches,
Curr. Opin. Struct. Biol., Vol.19, (2009), pp.251-259.

A. Serganov, L. Huang, D.J. Patel:
Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch.
Nature, Vol.458, (2009), pp.233-237.

V. Olieric, U. Rieder, K. Lang, A. Serganov, C. Schulze-Briese, R. Micura, P. Dumas, E. Ennifar:
A fast selenium derivatization strategy for crystallization and phasing of RNA structures,
RNA,Vol.15, (2009), pp.707-715.

A. Serganov, L. Huang, D.J. Patel:
Structural insights into amino acid binding and gene control by a lysine riboswitch,
Nature, Vol.455, (2008), pp.11263-11267.

S. Marzi, A.G. Myasnikov, A. Serganov, C. Ehresmann, P. Romby, M. Yusupov, B.P. Klaholz:
Structured mRNAs regulate translation initiation by binding to a dedicated site on the ribosome,
Cell, Vol.130, (2007), pp.1019-1031.