Main

Fields of interest:

• Cell signaling
• Surface receptors
• Protein kinases
• Phosphorylation

Recent publications:

J.P. Dawson, M.B. Berger, C-C. Lin, J. Schlessinger, M.A. Lemmon and K.M. Ferguson:
EGF receptor dimerization and activation require ligand-induced conformational changes in the dimer interface.
Mol. Cell Biol., Vol. 25, (2005), pp. 7734-7742.

S. Yamamoto, I. Yoshino, T. Shimazaki, M. Murohashi, R. F. Hevner, I. Lax, H. Okano, M. Shibuya, J. Schlessinger and N. Gotoh:
Essential role of Shp2-binding sites on the docking protein FRS2α for mammalian corticogenesis and for FGF2-dependent proliferation of cultured neural progenitor cells.
Proc. Natl. Acad. Sci. USA, Vol. 102 (2005), pp. 15983-15988.

Y.H. Yokote, K. Fujita, X. Jing, T. Sawada, S. Liang, L. Yao, X. Yan, Y. Zhang, J. Schlessinger and K. Sakaguchi:
Trans-activation of EphA4 and FGF-receptors mediated by direct interactions between their cytoplasmic domains.
Proc. Natl. Acad. Sci. USA, Vol. 102, (2005), pp. 18866-18871.

C. Furdui, E.D. Lew, J. Schlessinger and K.S. Anderson:
Autophosphorylation of FGFR1 kinase is mediated by a sequential and precisely ordered reaction.
Mol. Cell, Vol. 21, (2006), pp. 711-717.

E. Rohmann, H. Brunner, H. Kayserili, O. Uyguner, G. Nurnberg, E.D. Lew, A. Dobbie, V.P. Eswarakumar, A. Uzumcu, M. Emerouglu, J. Leroy, Y. Li, C. Becker, K. Lehnerdt, C.W.R.J. Cremers, M. Yuksel-Apak, P. Nurnberg, C. Kubisch, J. Schlessinger, H. von Bockhoven, B. Wollnick:
Mutations in different components of FGF-signaling in LADD syndrome.
Nature Genetics, Vol. 38, (2006), 414-417.

F. Özcan, P. Klein, M. Lemmon, I. Lax, J. Schlessinger:
On the nature of the high-affinity EGF-receptor binding sites on living cells.
Proc. Natl. Acad. Sci. USA, Vol. 103, (2006), pp. 5735-5740.

S. Lamprianou, N. Vacaresse, Y. Suzuki, H. Meziane, J.D. Buxbaum, J. Schlessinger and S. Harroch:
Receptor tyrosine phosphatase-γ (RPTPγ) is a marker for pyramidal cells and sensory neurons in the nervous system and is not necessary for normal development.
Mol. Cell Biol., Vol. 26, (2006), 5106-5119.

M.L. Galisteo, Y. Yang, J. Urena and J. Schlessinger:
Activation of the non-receptor protein tyrosine kinase Ack by multiple extracellular stimuli.
Proc. Natl. Acad. Sci. USA, Vol. 103, (2006), pp. 9796-9801.

J. Schlessinger and M.A. Lemmon:
Nuclear signaling by receptor tyrosine kinases: The first robin of spring.
Cell, Vol. 127, (2006), pp. 45-48.

V.P. Eswarakumar, F. Özcan, E.D. Lew, J.H. Bae, F. Tomé, C.J. Booth, D.J. Adams, I. Lax and J. Schlessinger:
Attenuation of signaling pathways stimulated by pathologically activated FGF-receptor 2 mutants prevents craniosynostosis.
Proc. Natl. Acad. Sci. USA, Vol. 103, (2006), pp. 18603-18608.

V.P. Eswarakumar and J. Schlessinger:
Skeletal overgrowth is mediated by deficiency in a specific isoform of fibroblast growth factor receptor-3.
Proc. Natl. Acad. Sci. USA, (2007), in press.