Main

Fields of interest:

• Membrane Biology

Recent publications:

P. Krishnamurthy, D.D. Ross, T. Nakanishi, K. Bailey-Dell, S. Zhou, K.E. Mercer, B. Sarkadi, B.P. Sorrentino and J.D. Schuetz:
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme,
J. Biol. Chem., Vol. 279, (2004), 24218-25.

B. Sarkadi, Cs. Özvegy-Laczka, K. Német and A. Váradi:
ABCG2 - a transporter for all seasons. Minireview,
FEBS Lett., Vol. 567, (2004), pp. 116-120.

Z. Szentpétery, A. Kern, K. Liliom, B. Sarkadi, A. Váradi and É. Bakos:
The role of the conserved glycines of ABC signature motifs of MRP1 in the communications between the substrate binding site and the catalytic centers,
J. Biol. Chem., Vol. 279, (2005), pp. 41670-41678.

C. Özvegy-Laczka, G. Várady, G. Köblös, O. Ujhelly, J. Cervenak, J.D. Schuetz, B.P. Sorrentino, G.J. Koomen, A. Váradi, K. Német, B. Sarkadi:
Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface,
J. Biol. Chem., Vol. 280, (2005), pp. 4219-4227.

N.B. Elkind, Z. Szentpétery, A. Apáti, C. Özvegy-Laczka, G. Várady, O. Ujhelly, K. Szabó, L. Homolya, A. Váradi, Buday, L., G. Kéri, K. Német and B. Sarkadi:
The multidrug transporter ABCG2 prevents tumor cell death induced by the EGF receptor inhibitor Iressa (ZD1839, Gefitinib),
Cancer Research, Vol. 65, (2005), pp. 1770-1777.

C. Ozvegy-Laczka, J. Cserepes, N.B. Elkind and B. Sarkadi:
Tyrosine kinase inhibitor resistance in cancer: role of ABC multidrug transporters,
Drug Resist Update, Vol. 8, (2005), pp. 15-26.

J. Cervenak, H. Andrikovics, Cs. Özvegy-Laczka, A. Tordai, K. Német, A. Váradi and B. Sarkadi:
The role of the Human ABCG2 Multidrug Transporter and its Variants in Cancer Therapy and Toxicology,
Cancer Letters, Vol. 234, (2005), pp. 62-72.

I. Szatmari, G. Vamosi, P. Brazda, B.L. Balint, S. Benko, L. Szeles, V. Jeney, C. Ozvegy-Laczka, A. Szanto, E. Barta, J. Balla, B. Sarkadi and L. Nagy:
Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells,
J. Biol. Chem., Vol. 281, (2006), pp. 23812-23823

M. Muller, I. Klein, S. Kopacsi, A.T. Remaley, E. Rajnavolgyi, B. Sarkadi and A. Varadi:
Co-expression of human ABCG5 and ABCG8 in insect cells generates an androstan stimulated membrane ATPase activity,
FEBS Lett., Vol. 580, (2006), pp. 6139-6144.

B. Sarkadi, L. Homolya, G. Szakács and A. Váradi:
Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System,
Physiol. Rev., Vol. 86, (2006), pp. 1179-1236.