Main

Fields of interest:

• tumor suppressor/oncogenes
• cancer biology
• developmental disorders
• ectodermal dysplasia
• transcription
• RNA splicing
• protein-protein interactions
• protein kinases
• DNA damage
• stress
• nitric oxide synthase
• cytokine/mitogens/receptors
• signaling
  

Recent publications:

Y. Huang, Li Z. Kim, T. Fomenkov, A. Fomenkov, E. Ratovitski:
AEC-associated p63 mutations lead to alternative splicing/protein stabilization of p63 and modulation of Notch signaling,
Cell Cycle., Vol. 4, (2005) pp.1440-1447.

E. Ratovitski, B. Trink, D. Sidransky:
P63 and P73: teammates or adversaries. Preview,
Cancer Cell., Vol. 9, (2006), pp. 1-2.

S. Upadhyay, C. Liu, A. Chatterjee, M. Hoque, M. Kim, J. Engles, W. Westra, B. Trink, E. Ratovitski, D. Sidransky:
LKB1/STK11 suppresses COX-2 induction and cellular invasion through PEA3 in lung cancer,
Cancer Res., Vol. 66, (2006), pp. 7870-7879.

M. Sommer, N. Poliak, S. Upadhyay, B. Nelkin, L. Donehower, D. Sidransky, E. Ratovitski:
ΔNp63α overexpression induces downregulation of SIRT1 and an accelerated aging phenotype in the mouse,
Cell Cycle., Vol. 5, (2006), pp. 2005-2011.

A. Carvalho, A. Chuang, W. Jiang, J. Lee, S. Begum, L. Poeta, M. Zhao, C. Jeronimo, R. Henrique, C. Nayak, H. Park, M. Brait, C. Liu, S. Zhou, W. Koch, V. Fazio, E. Ratovitski, B. Trink, W. Westra, D. Sidransky, C. Moon, J. Califano:
Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma,
Cancer Res., Vol. 66, (2006), pp. 9401-9407.

G. Wu, Z. Guo, A. Chatterjee, X. Huang, E. Rubin, F. Fu, E. Mambo, X. Chang, M. Osada, M.S. Kim, C. Moon, J. Califano, E. Ratovitski, S. Gollin, S. Sukumar, D. Sidransky, B. Trink:
Overexpression of GPI transamidase subunits, PIG-T and GPAA1, Individually Induce Tumorigenesis and Contribute to Invasion in Human Breast Cancer,
Cancer Res., Vol. 66, (2006), pp. 9829-9836.

B. Trink, M. Osada, E. Ratovitski, D. Sidransky:
P63 transcriptional regulation of epithelial integrity and tumorigenesis. Review,
Cell Cycle., Vol. 6, (2007), pp. 240-245.

Y. Huang, M.O. Hoque, F. Wu, B. Trink, D. Sidransky, E. Ratovitski:
Midkine induces epithelial-mesenchymal transition through the Notch2-Jak2-Stat3 signaling in human keratinocytes,
Cell Cycle., Vol. 7, (2008), pp. 1613-1622.

Y. Huang, T. Sen, J.K. Nagpal, M.S. Kim, S. Upadhyay, B. Trink, D. Sidransky, E. Ratovitski:
ATM kinase is a master switch for the ΔNp63α protein phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage,
Cell Cycle., Vol. 7, (2008), pp. 2846-2855.