Main

Fields of Interest:

Microbiology

Bacterial genetics

Pathogenesis

Molecular biology

Gene regulation

Recent publications:

Carroll, R. K., S. B. Beres, I. Sitkiewicz, L. Peterson, R. K. Matsunami, D. A. Engler, A. R. Flores, P. Sumby & J. M. Musser, (2011):
Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus.
Epidemics 3: 159-170.

Prosen, K. R., R. K. Carroll, W. N. Burda, C. N. Krute, B. Bhattacharya, M. L. Dao, E. Turos & L. N. Shaw, (2011):
The impact of fatty acids on the antibacterial properties of N-thiolated beta-lactams.
Bioorg Med Chem Lett 21: 5293-5295.

Carroll, R. K. & J. M. Musser, (2011):
From transcription to activation: how group A streptococcus, the flesh-eating pathogen, regulates SpeB cysteine protease production.
Mol Microbiol 81: 588-601.

Carroll, R. K., S. A. Shelburne, 3rd, R. J. Olsen, B. Suber, P. Sahasrabhojane, M. Kumaraswami, S. B. Beres, P. R. Shea, A. R. Flores & J. M. Musser, (2011):
Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice.
J Clin Invest 121: 1956-1968.

Olsen, R. J., M. Ashraf, V. E. Gonulal, A. A. Ayeras, C. Cantu, P. R. Shea, R. K. Carroll, T. Humbird, J. L. Greaver, J. L. Swain, E. Chang, W. Ragasa, L. Jenkins, K. P. Lally, T. Blasdel, P. Cagle & J. M. Musser, (2010):
Lower respiratory tract infection in cynomolgus macaques (Macaca fascicularis) infected with group A Streptococcus.
Microb Pathog 49: 336-347.

Beres, S. B., R. K. Carroll, P. R. Shea, I. Sitkiewicz, J. C. Martinez-Gutierrez, D. E. Low, A. McGeer, B. M. Willey, K. Green, G. J. Tyrrell, T. D. Goldman, M. Feldgarden, B. W. Birren, Y. Fofanov, J. Boos, W. D. Wheaton, C. Honisch & J. M. Musser, (2010):
Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics.
Proc Natl Acad Sci U S A 107: 4371-4376.

Shelburne, S. A., 3rd, D. B. Keith, M. T. Davenport, S. B. Beres, R. K. Carroll & J. M. Musser, (2009):
Contribution of AmyA, an extracellular alpha-glucan degrading enzyme, to group A streptococcal host-pathogen interaction.
Mol Microbiol 74: 159-174.

Carroll, R. K., X. Liao, L. K. Morgan, E. M. Cicirelli, Y. Li, W. Sheng, X. Feng & L. J. Kenney, (2009):
Structural and functional analysis of the C-terminal DNA binding domain of the Salmonella typhimurium SPI-2 response regulator SsrB.
J Biol Chem 284: 12008-12019.

Walthers, D., R. K. Carroll, W. W. Navarre, S. J. Libby, F. C. Fang & L. J. Kenney, (2007):
The response regulator SsrB activates expression of diverse Salmonella pathogenicity island 2 promoters and counters silencing by the nucleoid-associated protein H-NS.
Mol Microbiol 65: 477-493.

O'Croinin, T., R. K. Carroll, A. Kelly & C. J. Dorman, (2006):
Roles for DNA supercoiling and the Fis protein in modulating expression of virulence genes during intracellular growth of Salmonella enterica serovar Typhimurium.
Mol Microbiol 62: 869-882.

Kelly, A., M. D. Goldberg, R. K. Carroll, V. Danino, J. C. Hinton & C. J. Dorman, (2004):
A global role for Fis in the transcriptional control of metabolism and type III secretion in Salmonella enterica serovar Typhimurium.
Microbiology 150: 2037-2053.