Main

Fields of interest:

• Molecular pharmacology
• Molecular mechanisms of drug action
• Drug-target interactions
• Protein structure and dynamics
• NMR spectroscopy
   

Recent publications:

E.V. Ivanova, E.Z. Alkalaeva, B. Birdsall P.M. Kolosov, V.I. Polshakov and L.L. Kisselev:
Interface of the Interaction of the middle domain of human translation termination factor eRF1 with eukaryotic Ribosomes,
Mol. Biol. (Rus)., Vol. 42, (2008), pp. 1056-1066.

V.V. Vostrikov, A.A. Selishcheva, G.M. Sorokoumova, Y.N. Shakina, V.I. Shvets, O.Y. Savelev and V.I. Polshakov:
Distribution coefficient of rifabutin in liposome/water system as measured by different methods, 
Eur. J. Pharm. Biopharm., Vol. 68, (2008), pp. 400-405.

N.V. Kovalevskaya, Y.D. Smurnyy, B. Birdsall, J. Feeney and V.I. Polshakov:
Structural factors that determine selectivity of binding of antibacterial drug trimethoprim with dihydrofolate reductase,
Khim.-Pharm. Zh. (Russ), Vol. 7, (2007), pp. 8-11.

E.V. Ivanova, P.M. Kolosov, B. Birdsall, G. Kelly, A. Pastore, L.L. Kisselev and V.I. Polshakov:
Eukaryotic class-1 translation termination factor eRF1: the NMR structure of the middle domain involved in triggering ribosome-dependent peptidyl-tRNA hydrolysis,
FEBS Journal, Vol. 274, (2007), pp. 4223-37

V.I. Polshakov, B. Birdsall and J. Feeney:
Effects of co-operative ligand binding on protein amide NH hydrogen exchange,
J. Mol. Biol., Vol. 356, (2006), pp. 886-903.

E.V. Ivanova, P.M. Kolosov, B. Birsall, L.L. Kisselev and V.I. Polshakov:
NMR assignments of the middle domain of human polypeptide release factor eRF1,
J. Biomol. NMR, Vol. 36, (2006), Suppl. 1, p. 8.

N.V. Kovalevskaya, Y.D. Smurnyy, V.I. Polshakov, B. Birdsall, A.F. Bradbury, T. Frenkiel and J. Feeney:
Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH,
J. Biomol. NMR, Vol. 33, (2005), pp. 69-72.