Main

Fields of interest:

• Protein engineering
• Protein-protein recognition
• Proteases and their protein inhibitors
• Phage display
• Rho GTPases
• Neuronal migration

Recent publications:

M. Mateja, T. Cierpicki, M. Paduch, Z.S. Derewenda and J. Otlewski:
The Dimerization Mechanism of Lis1 and Its Implication for Proteins Containing the LisH Motif,
J. Mol. Biol., Vol. 357, (2006), pp. 621-631.

O. Pasternak, G.D. Bujacz, Y. Fujimoto, F. Jelen, J. Otlewski, M.M. Sikorski and M. Jaskolski:
Unusual Zeatin Binding Revealed by Atomic-resolution Structure of Cytokinin-specific Binding Protein,
Plant Cell, Vol. 18, (2006), pp. 2622-2634.

A. Oleksy, L. Opalinski, U. Derewenda, Z.S. Derewenda and J. Otlewski:
The Molecular Basis of RhoA Specificity in the Guanine Nucleotide Exchange Factor PDZ-RhoGEF,
J. Biol. Chem., Vol. 281, (2006), pp. 32891-32897.

M. Zakrzewska, D. Krowarsch, A. Wiedlocha, S. Olsnes and J. Otlewski:
Structural Requirements of FGF-1 for Receptor Binding and Translocation into Cells,
Biochemistry, Vol. 45, (2006), pp. 15338-15348.

J. Otlewski, F. Jelen, M. Zakrzewska and A. Oleksy:
The Many faces of Protease - Protein Inhibitor Interaction,
EMBO J., Vol. 24, (2005), pp. 1303-1310.

M. Zakrzewska, D. Krowarsch, A. Wiedlocha, S. Olsnes and J. Otlewski:
Highly Stable Mutants of Human Fibroblast Growth Factor-1 Exhibit Prolonged Biological Action,
J. Mol. Biol., Vol. 352, (2005), pp. 860-875.

M.H. Kim, D. Cooper, A. Oleksy, Y. Devedjiev, U. Derewenda, O. Reiner, J. Otlewski and Z.S. Derewenda:
The Structure of the N-terminal Domain of the Product of the Lissencephaly Gene Lis1 and Its Functional Implications,
Structure, Vol. 12, (2004), pp. 987-998.

U. Derewenda, A. Oleksy, A.S. Stevenson, J. Korczynska, Z. Dauter, A.P. Somlyo, J. Otlewski, A.V. Somlyo and Z.S. Derewenda:
The Crystal Structure of RhoA in Complex with the DH/PH Fragment of PDZRhoGEF, an Activator of the Ca(2+) Sensitization Pathway in Smooth Muscle,
Structure, Vol. 12, (2004), pp. 1955-1965.

B.S. Kang, D. Cooper, F. Jelen, Y. Devedjiev, U. Derewenda, Z. Dauter, J. Otlewski and Z.S. Derewenda:
PDZ-tandem of Human Syntenin: Crystal Structure and Functional Properties,
Structure, Vol. 11, (2003), pp. 459-468.

M.H. Kim, T. Cierpicki, U. Derewenda, D. Krowarsch, Y. Feng, Y. Devedjiev, Y. Dauter, C.A. Walsh, J. Otlewski, J.H. Bushweller and Z.S. Derewenda:
DCX-Domain Tandems of Doublecortin and Doublecortin-like Kinase: Implications for Microtubule Regulation,
Nature Struct. Biol., Vol. 10, (2003), pp. 324-333.