Main

Fields of interest:

Bacterial pathogenesis

Drug discovery   

Transcriptional regulation in prokaryotes

Recent publications: 

T.E. Ballard, X. Wang, I. Olekhnovich, T. Koerner, C. Seymour, J. Salamoun, M. Warthan, P.S. Hoffman, T. L. Macdonald:
Synthesis and antimicrobial evaluation of nitazoxanide-based analogues: identification of selective and broad spectrum activity,
Chem Med Chem., Vol.6(2), (2011), pp.362-77.

T.E. Ballard, X. Wang, I. Olekhnovich,T. Koerner, C. Seymour, P. Hoffman, T.L. Macdonald:
Biological Activity of Modified and Exchanged 2-Amino-5-Nitrothiazole Amide Analogues of Nitazoxanide,
Bioorg. Med. Chem. Lett., Vol. 20(12), (2010), pp.3537-9.

I.N. Olekhnovich, A. Goodwin, P.S. Hoffman:
Characterization of the NAD(P)H oxidase and metronidazole reductase activities of the RdxA nitroreductase of Helicobacter pylori,
FEBS, Vol.276(12), (2009), pp.3354–3364.

S. Ding, I. Olekhnovich, T. Cover, R. Peek, M. Smith,  J. Goldberg:
Helicobacter pyloriand mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells,
FEMS Immunol. & Med. Microbiol., Vol.53, (2008), pp.385-394.

I.N. Olekhnovich and R.J. Kadner:
Role of nucleoid-associated proteins Hha and H-NS in expression of Salmonella enterica activators HilD, HilC, and RtsA required for cell invasion,
J. Bacteriol., Vol. 189, (2007), pp. 6882-6890

I.N. Olekhnovich and R.J. Kadner:
Crucial roles of both flanking sequences in silencing of the hilA promoter in Salmonella enterica,
J. Mol. Biol., Vol. 357, (2006), pp. 373-386.

I.N. Olekhnovich nad R.J. Kadner:
Contribution of RpoA C-terminal domain to stimulation of the Salmonella enterica hilA promoter by HilC and HilD,
J. Bacteriol., Vol. 186, (2004), pp. 3249-3253

I.N. Olekhnovich and R.J. Kadner:
Mutational scanning and affinity cleavage analysis of UhpA-binding sites in the Escherichia coli uhpT promoter,
J. Bacteriol., Vol. 184, (2002), pp. 2682-2691.

I.N. Olekhnovich and R.J. Kadner:
DNA sites for binding of the HilC and HilD virulence regulatory proteins of Salmonella enterica serovar Typhimurium,
J. Bacteriol., Vol. 142, (2002), pp. 4148-4160

I.N. Olekhnovich and G.N. Gussin:
Effect of mutations in the P. putida miaA gene: regulation of the trpE and trpGDC operons in P. putida by attenuation,
J. Bacteriol., Vol. 183, (2001), pp. 3256-3260