Main

Fields of interest:

• Aging
• Neurodegenerative disorders
• Synaptic plasticity
• Growth factor signaling
• Oxidative stress
• Cell death

Recent publications:

B. Cheng, M.P. Mattson:
NGF and bFGF protect rat and human central neurons against hypoglycemic damage by stabilizing calcium homeostasis,
Neuron, Vol. 7, (1991), pp. 1031-1041.

K. Furukawa, S.W. Barger, E. Blalock, M.P. Mattson:
Activation of K+ channels and suppression of neuronal activity by secreted b-amyloid precursor protein,
Nature, Vol. 379, (1996), pp. 74-78.

Q. Guo, W. Fu, B.L. Sopher, M.W. Miller, C.B. Ware, G.M. Martin, M.P. Mattson:
Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knockin mice,
Nature Med., Vol. 5, (1999), pp. 101-107.

W. Duan, Z. Guo, H. Jiang, M. Ware, X.J. Li, M.P. Mattson:
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice,
PNAS, Vol. 100, (2003), pp. 2911-2916.

R.M. Anson, Z. Guo, R. de Cabo, T. Iyun, M. Rios A. Hagepanos, D.K. Ingram, M.A. Lane, M.P. Mattson:
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake,
PNAS, Vol. 100, (2003), pp. 6216-6220.

R.G. Cutler, J. Kelly, W.A. Pedersen, A. Tammara, K. ,Hatanpaa, J.C. Troncoso,
M.P. Mattson:
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease,
PNAS, Vol. 101, (2004), pp. 2070-2075.

I.I. Kruman, R.P. Wersto, F. Cardozo-Pelaez, L. Smilenov, S.L. Chan, F.J. Chrest,
R. Emokpae, M. Gorospe, M.P. Mattson:
Cell cycle activation linked to neuronal cell death initiated by DNA damage,
Neuron, Vol. 41, (2004), pp. 549-561.

M.P. Mattson:
Pathways towards and away from Alzheimer's disease,
Nature, Vol. 430, (2004), pp. 631-639.

N. Maswood, J. Young, E. Tilmont, Z. Zhang, D.M. Gash, G.A. Gerhardt, R. Grondin,
G.S. Roth, J. Mattison, M.A. Lane, R.E. Carson, R.M. Cohen, P.R. Mouton, C. Quigley,
M.P. Mattson, D.K. Ingram:
Caloric restriction increases GDNF levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease,
PNAS, Vol. 101, (2004), pp. 18171-18176.

T.V. Arumugam, S.L. Chan, D.G. Jo, G. Yilmaz, S.C. Tang, M. Gleichmann, A. Cheng,
E. Okun, V.D. Dixit, S. Chigurupati, M. Mughal, X. Ouyang, L. Miele, T. Magnus,
S. Poosala, D.N. Granger, M.P. Mattson:
Gamma secretase-mediated notch signaling worsens brain damage and functional outcome in ischemic stroke,
Nature Med., May 7, (2006) [Epub ahead of print].