Main

Fields of interest:

• Molecular genetics of cancer
• Identification of tumour antigens
• Antigen microarrays
• Cancer immunotherapy
• Cancer pharmacogenetics

Recent publications:

Z. Kalniņa, K. Siliņa, I. Meistere, P. Zayakin, A. Rivosh, A. Ābols, M. Leja, O. Minenkova, D. Schadendorf and A. Linē:
Evaluation of T7 and Lambda phage display systems for survey of autoantibody profiles in cancer patients,
J. Immunol. Methods, in press

Z. Kalniņa, K. Siliņa and A. Linē:
Autoantibody profiles as biomarkers for response to therapy and early detection of cancer,
Curr. Cancer Ther. Rev., in press

Z. Kalnina, K. Silina, P. Zajakin and A. Line:
Alterations of pre-mRNA splicing in cancer,
Genes, Chromosomes, Cancer, Vol. 42, (2005), pp. 342-57.

G. Li, A. Miles, A. Line and R.C. Rees:
Identification of tumour antigens by serological analysis of cDNA expression cloning.
Cancer Immunol. Immunother., Vol. 53, (2004), pp. 139-43.

A. Line, A. Stengrevics, Z. Slucka, G. Li, E. Jankevics and R.C. Rees:
Serological identification and expression analysis of gastric cancer-associated genes,
Br. J. Cancer, Vol. 86, (2002), pp. 1824-1830.

A. Line, Z. Slucka, A. Stengrevics, K. Silina, G. Li and R.C. Rees:
Characterisation of tumour-associated antigens in colon cancer,
Cancer Immunol. Immunother., Vol. 51, (2002), pp. 574-582.

A. Line, Z. Slucka, A. Stengrevics, G. Li and R.C. Rees:
Altered splicing pattern of TACC1 mRNA in gastric cancer,
Cancer Genet. Cytogenet., Vol. 139, (2002), pp. 78-83.

V.I. Petuhov, I. Strozha, A. Zhilevich, D. Bondare, A. Line, E. Jankevics, A. Tsimanis, A. Treimane and A. Krumina:
Effectiveness of alfa-interferon therapy and bcr-abl transcripts in patients with chronic myeloid leukemia (CML),
Gematol. Transfuziol., Vol. 44, (1999), pp. 3-6. [in Russian]

V.I. Petuhov, D. Bondare, I. Strozha, E. Jankevics, A. Line, A. Zhilevich, Z. Kovaleva, L. Savastjanova, M. Lielpetere, S. Nikulshin, H. Grante, R. Treimane and I. Teilane:
Three cases of BCR-ABL-positive leukaemia in one family,
Gematol. Transfuziol., Vol. 44, (1999), pp. 46-47. [in Russian]

D. Bondare, A. Zilevica, I. Stroza, G. Feldmane, A. Volrate, G. Kluce, V. Petuhovs, A. Cimanis, H. Grante, I. Teilane, R. Treimane, A. Line:
Interferon-alpha therapy in chronic myeloid leukemia and detection of bcr/abl transcripts,
Proc. Latvian Acad. Sci., Vol. 52, (1998), pp. 102-107.