Main

Fields of interest:

• Systems biology
• Genomics
• Genetics

Recent publications:

Chavez, L., et al.,
Computational analysis of genome-wide DANN methylation during the differentiation of human embryonic stem cells along the endodermal lineage.
Genome Res, 2010.

Cheng, X., et al.,
Screening of human gene promoter activities using transfected-cell arrays.
Gene, 2010. 450 (1-2):p. 48-54

Gruning, N.M., Lehrach H., and Ralser M.,
Regulatory crosstalk of the metabolic network.
Trends Biochem Sci, 2010. 35(4):p. 220-7.

Hudson, T.J., et al.,
International Cancer Genome Consortium (2010): International network of cancer genome projects.
Nature, 15; 464 (7291): 993-8.

Warnatz HJ, Querfurth R, Guerasimova A, Cheng X, Haas SA, Hufton AL, Manke T, Vanhecke D, Nietfeld W, Vingron M, Janitz M, Lehrach H, Yaspo ML.
Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.
Nucleic Acids Res. 2010 May 21.

Schweiger MR, Kerick M, Timmermann B, Albrecht MW, Borodina T, Parkhomchuk D, Zatloukal K, Lehrach H. (2009):
Genome-wide massively parallel sequencing of formaldehyde fixed-paraffin embedded (FFPE) tumor tissues for copy-number- and mutation-analysis.
PLoS One 4(5): e5548.

Ralser M, Wamelink MM, Latkolik S, Jansen EE, Lehrach H, Jakobs C. (2009):
Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response.
Nat Biotechnol. 27(7): 604-5.

Parkhomchuk D, Borodina T, Amstislavskiy V, Banaru M, Hallen L, Krobitsch S, Lehrach H, Soldatov A.
Transcriptome analysis by strand-specific sequencing of complementary DNA.
Nucleic Acids Res. 2009 Oct;37(18):e123. Epub 2009 Jul 20.

Hache H, Wierling C, Lehrach H, Herwig R.
GeNGe: systematic generation of gene regulatory networks.
Bioinformatics. 2009 May 1;25(9):1205-7. Epub 2009 Feb 27.

Sultan M, Schulz MH, Richard H, Magen A, Klingenhoff A, Scherf M, Seifert M, Borodina T, Soldatov A, Parkhomchuk D, Schmidt D, O'Keeffe S, Haas S, Vingron M, Lehrach H, Yaspo ML. (2008):
A global view of gene activity and alternative splicing by deep sequencing of the human transcriptome.
Science. 15; 321 (5891): 956-60.