Main

Fields of interest:

• enzymology
• proteases and inhibitors
• hemostasis and fibrinolysis
• endothelium and blood cells

Recent publications:

Z. Rottenbergerand, K.Kolev:
Matrix metalloproteinases at key junctions in the pathomechanism of stroke,
Cent.Eur. J. Biol., Vol. 6 (2011), pp.471-485

C. Longstaff, C.Thelwell, S. Williams, M. Silva, L. Szabó and K.Kolev K:
The interplay between  tissue  plasminogen activator domains and  fibrin structures in the regulation of fibrinolysis: kinetic and microscopic studies,
Blood, Vol. 117, (2011), pp. 661-668

N. Wohner, P.Sótonyi, R.Machovich, L.Szabó, K.Tenekedjiev,M. Silva, C.Longstaff and K.Kolev:
Lytic resistance of fibrin containing red blood cells,
Arterioscl.Thromb.Vasc. Biol., Vol. 31,(2011), pp.2306-2313

I. Varjú, P.Sótonyi, R.Machovich, L. Szabó, K.Tenekedjiev, M. Silva, C.Longstaff C and K.Kolev:
Hindered dissolution of fibrin formed under mechanical stress,
J.Thromb.Haemost.,Vol. 9, (2011), pp. 979-986

N. Wohner, Z.Keresztes, P.Sótonyi, L. Szabó, E.Komorowicz, R.Machovich and K.Kolev:
Neutrophil granulocyte-dependent proteolysis enhances platelet adhesion to arterial wall under high-shear flow,
J.Thromb.Haemost.,Vol. 8, (2010), pp. 1624-1631

A. Tanka-Salamon, K. Tenekedjiev, R. Machovich and K. Kolev:
Suppressed catalytic efficiency of plasmin in the presence of long-chain fatty acids: Identification of kinetic parameters from continuous enzymatic assay with Monte Carlo simulation,
FEBS J., Vol. 275, (2008), pp. 1274-1282

G. Rábai, B. Váradi, C. Longstaff, P. Sótonyi, V. Kristóf, F. Timár, R. Machovich and K. Kolev:
Fibrinolysis in a lipid environment: modulation through release of free fatty acids,
J. Thromb. Haemost., Vol. 5, (2007), pp. 1265-1273.

R. Galántai, K. Módos, J. Fidy, K. Kolev and R. Machovich:
Structural basis of the cofactor function of denatured albumin in plasminogen activation by tissue-type plasminogen activator,
Biochem. Biophys. Res. Comm., Vol. 341, (2006), pp. 736-741.

K. Kolev, C. Longstaff and R. Machovich:
Fibrinolysis at the fluid-solid interface of thrombi,
Curr. Medic. Chem. Cardiovasc. Hematol. Agents, Vol. 3, (2005),  pp. 341-355.

B. Váradi, K. Kolev, K. Tenekedjiev, G. Mészáros, I. Kovalszky, C. Longstaff and R. Machovich:
Phospholipid-barrier to fibrinolysis: role for the anionic polar head charge and the gel-phase crystalline structure,
J. Biol. Chem., Vol. 279, (2004),  pp. 39863-39871.

K. Kolev and R. Machovich:
Molecular and cellular modulation of fibrinolysis,
Thromb. Haemost., Vol. 89, (2003), pp. 610-621.

K. Kolev, K. Tenekedjiev, J. Gombás, B. Váradi, K. Ajtai, I. Kovalszky and R. Machovich:
Myosin: a non-covalent stabilizer of fibrin in the process of clot dissolution,
Blood, Vol. 101, (2003), pp. 4380-4386.