Main

Fields of interest:
Organic chemistry
Organic synthesis
Organometallic chemistry

Recent publications:
X.M. Sun, K. Manabe, W. W.-L. Lam, N. Shiraishi, J. Kobayashi, M. Shiro, H. Utsumi, S. Kobayashi
Synthesis of a New Chiral Source, (1R,2S)-1-Phenylphospholane-2-carboxylic Acid, via a Key Intermediate ?-Phenylphospholanyllithium Borane Complex. Configurational Stability and X-ray Crystal Structure of ?-Monophosphinoalkyllithium Borane Complex
Chem. Eur. J., 11, 361-368 (2005).

S. Ishikawa, T. Hamada, K. Manabe, S. Kobayashi
Catalytic Asymmetric Hydroxymethylation of Silicon Enolates Using an Aqueous Solution of Formaldehyde with a Chiral Scandium Complex
J. Am. Chem. Soc., 126, 12236-12237 (2004).

C. Ogawa, M. Sugiura, S. Kobayashi
Stereospecific, Enantioselective Allylation of -Hydrazono Esters Using Allyltrichlorosilanes with BINAP Dioxides as Neutral-Coordinate Organocatalysts
Angew. Chem., Int. Ed. Engl., 116, 6653-6655 (2004).

R. Matsubara, P. Vital, Y. Nakamura, H. Kiyohara, S. Kobayashi
Highly Diastereo- and Enantioselective Reactions of Enecarbamates with an Aldehyde
Tetrahedron, 60, 9769-9784 (2004).

R. Akiyama, T. Sagae, M. Sugiura, S. Kobayashi
Efficient Synthesis of N-Acyl- -Amino Acids via Polymer Incarcerated Palladium- Catalyzed Amidocarbonylation
J. Organomet. Chem., in 689, 3806-3809 (2004).

S. Kobayashi, M. Sugiura, C. Ogawa
Neutral Coordinate- Organocatalysts in Organic Synthesis: Allylation of Acylhydrazones with Allyltrichlorosilanes
Adv. Synth. Catal., 346, 1023-1034 (2004).

Y. Yamashita, S. Kobayashi
Zirconium-Catalyzed Enantioselective [3+2] Cycloaddition of Hydrazones to Olefins Leading to Optically Active Pyrazolidine, Pyrazoline, and 1.3-Diamine Derivatives
J. Am. Chem. Soc., 126, 11279-11282 (2004).

J. Kobayashi, M. Nakamura, Y. Mori, Y. Yamashita, S. Kobayashi
Catalytic Enantio- and Diastereoselective Aldol Reactions of Glycine- Derived Silicon Enolate with Aldehydes: An Efficient Approach to the Asymmetric Synthesis of Anti-?-Hydroxy - ? -Amino Acid Derivatives
J. Am. Chem. Soc., 126, 9192-9193 (2004).

S. Iimura, K. Manabe, S. Kobayashi
Hydrophobic Polymer -Supported Scandium Catalyst for Carbon-Carbon Bound-Forming Reactions in Water
Tetrahedron, 60, 7673-7678 (2004).

R. Matsubara, Y. Nakamura, S. Kobayashi
Highly Diastereo- and Enantioselective Reactions of Enecarbamates with Ethyl Glyoxylate Leading to Both Optically Active Syn- and Anti- ? -alkyl- ? -hydroxy Imines and Ketones
Angew. Chem., Int. Ed., 43, 3258-3260 (2004).

K. Okamoto, R. Akiyama, S. Kobayashi
Suzuki-Miyaura Coupling Catalyzed by the Polymer Incarcerated Palladium (PI Pd), a Highly Active Recoverable and Reusable Pd Catalyst
Org. Lett., 6, 1987-1990 (2004).

T. Hamada, K. Manabe, S. Kobayashi
Enantio- and Diastereoselective, Stereospecific Mannich-Type Reaction in Water
J. Am. Chem. Soc., 126, 7768-7769 (2004).

S. Kobayashi, H. Kiyohara, Y. Nakamura, R. Matsubara
Catalytic Asymmetric Synthesis of ?-Amino Phosphonates Using Enantioselective Carbon-Carbon Bond-Forming Reactions
J. Am. Chem. Soc., 126, 6558-6559(2004).

J. Kobayashi, Y. Mori, K. Okamoto, R. Akiyama, M. Ueno, T. Kitamori, S. Kobayashi
A Microfluidic Device for Conducting Gas-Liquid-Solid Hydrogenation Reactions
Science, 304, 1305-1308(2004).

M. Sugiura, K. Hirano, S. Kobayashi
?-Aminoallylation of Aldehydes with Ammonia: Stereoselective Stynthesis of Homoallylic Primary Amines
J. Am. Chem. Soc., 126, 7182-7183 (2004).

K. Okamoto, R. Akiyama, S. Kobayashi
Recoverable, Reusable, Highly Active, and Sulfur-tolerant Polymer Incarcerated Palladium for Hydrogenation
J. Org. Chem., 69, 2871-2873 (2004).

N. Aoyama, K. Manabe, S. Kobayashi
Iron(III) chloride as a water-compatible Lewis acid for diastereoselective aldol reactionsin water in the presence of a surfactant
Chem. Lett., 33, 312-313 (2004).

S. Kobayashi, M. Ueno, S. Saito, Y. Mizuki, H. Ishitani, Y. Yamashita
Air-Stable, Storable, and Highly Efficient Chiral Zirconium Catalysts for Enantioselective Mannich-type, aza Diels-Alder, Aldol, and Hetero Diels-Alder Reactions
Proc. Natl. Acad. Sci. U.S.A., 101, 5476-5481 (2004).

C. Ogawa, H. Konishi, M. Sugiura, S. Kobayashi
Phosphine Oxides as Efficient Neutral Coordinate-Organocatalysts for Stereoselective Allylations of N-Acylhydrazones
Org. Biomol. Chem., 2004, 446-448.

R. Matsubara, Y. Nakamura, S. Kobayashi
Copper(II)-catalyzed Highly Enantioselective Addition of Enamides to Imines. The Use of Enamides as Nucleophiles in Asymmetric Catalysis
Angwe. Chem. Int. Ed., 43, 1679-1681 (2004).

I. Komoto, S. Kobayashi
Lewis Acid Catalysis in Supercritical Carbon Dioxide (scCO2). Use of Poly(ethyleneglycol) Derivatives and Perfluoroalkylbenzenes as Surfactant Molecules which Enable Efficient Catalysis in scCO2,
J. Org. Chem., 69, 680-688 (2004).