Main

Fields of interest:

Enzyme chemistry and biotechnology;  Antimicrobial materials; Stability, stabilization, and formulatins of pharmaceutical proteins and nucleic acids; Enzymes as stereoselective catalysts in organic syntheses

Representative publications:

Schaer, T.P., Stewart, S., Hsu, B.B., Klibanov, A.M.:
Hydrophobic polycationic coatings that inhibit biofilms and support bone healing during infection.
Biomaterials, Vol. 33, (2012), pp. 1245-1254.

Hsu, B.B., Wong, S.Y., Hammond, P.T., Chen, J., Klibanov, A.M.:
On the mechanism of influenza virus inactivation by immobilized hydrophobic polycations,
Proc. Natl. Acad. Sci. USA,Vol. 108, (2011), pp. 61-66.

Wong, S.Y., Moskowitz, J.S., Veselinovic, J., Rosario, R.A., Timachova, K., Blaisse, M.R., Smith, R.C., Klibanov, A.M., Hammond, P.T.:
Dual functional polyelectrolyte multilayer coatings for implants: permanent microbicidal base with controlled release of therapeutic agents,
J. Am. Chem. Soc.,  Vol. 132, (2010), pp. 17840-17848.

Agresti, J.J., Antipov, E., Abate, A.R., Ahn, K., Rowat, A.C., Baret, J.-C., Marquez, M., Klibanov, A.M., Griffiths, A.D., Weitz, D.A.:
Ultrahigh-throughput screening in drop-based microfluidics for directed evolution,
Proc. Natl. Acad. Sci. USA, Vol. 107, (2010), pp. 4004-4009.

Antipov, E., Cho, A.E., Klibanov, A.M.:
How a single-point mutation in horseradish peroxidase markedly enhances enantioselectivity,
J. Am. Chem. Soc., Vol. 131, (2009), pp. 11155-11160.

Thomas, M., Lu, J.J., Zhang, C.C., Chen, J., Klibanov, A.M.:
Novel superior polycationic vectors for gene delivery prepared by high-throughput synthesis and screening of a combinatorial library.
Pharm. Res., Vol. 24, (2007), pp. 1564-1571.

Haldar, J., An, D., Alvarez de Cienfuegos, L., Chen, J., Klibanov, A.M.:
Polymeric coatings that inactivate both influenza virus and pathogenic bacteria.
Proc. Natl. Acad. Sci. USA,Vol. 103, (2006), pp. 17667-17671.

Thomas, M., Lu, J.J., Ge, Q., Zhang, C., Chen, J., Klibanov, A.M.:
Full deacylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung,
Proc. Natl. Acad. Sci. USA,Vol. 102, (2005), pp. 5679-5684.

Chakrabarti, R., Klibanov, A.M.:
Nanocrystals modified by peptide nucleic acids (PNAs) for selective self-assembly and DNA detection.,
J. Am. Chem. Soc., Vol. 125, (2003), pp. 12531-12540.

Klibanov, A.M.:
Improving enzymes by using them in organic solvents.
Nature,Vol. 409, (2001), pp. 241-246.