Main

Fields of interest:

• Molecular biophysics and pharmacology

Recent publications:

O. Brabec, K. Stehlikova, J. Malina, M. Vojtiskova, J. Kasparkova:
Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A,
Arch. Biochem. Biophys., Vol. 446, (2006), pp. 1-10.


H. Pivonkova, M. Brazdova, J. Kasparkova, V. Brabec, M. Fojta:
Recognition of cisplatin-damaged DNA by p53 protein: Critical role of the p53 C-terminal domain,
Biochem. Biophys. Res. Commun., Vol. 339, (2006), pp. 477-484.


Y. Najajreh, Y. Ardeli-Tzaraf, J. Kasparkova, P. Heringova, D. Prilutski, L. Balter, S. Jawbry, E. Khazanov, J. M. Perez, Y. Barenholz, V. Brabec, D. Gibson:
Interactions of Platinum Complexes Containing Cationic, Bicyclic, Nonplanar Piperidinopiperidine Ligands with Biological Nucleophiles,
J. Med. Chem., Vol. 49, (2006), pp. 4674-4683.


Y. Najajreh, E. Khazanov, S. Jawbry, Y. Ardeli-Tzaraf, J. M. Perez, J. Kasparkova, V. Brabec, Y. Barenholz, D. Gibson:
Cationic Nonsymmetric Transplatinum Complexes with Piperidinopiperidine Ligands. Preparation, Characterization, in Vitro Cytotoxicity, in Vivo Toxicity, and Anticancer Efficacy Studies,
J. Med. Chem., Vol. 49, (2006), pp. 4665-4673.


J. Kasparkova, O. Novakova, O. Vrana, F. Intini, G. Natile, V. Brabec:
Molecular aspects of antitumor effects of a new platinum(IV) drug
10.1124/mol.106.027730,
Mol. Pharmacol., (2006) mol.106.027730.


O. Novakova, J. Kasparkova, V. Bursova, C. Hofr, M. Vojtiskova, H. Chen, P. J. Sadler, V. Brabec:
Conformation of DNA modified by monofunctional Ru(II) arene complexes: recognition by DNA-binding proteins and repair. Relationship to cytotoxicity,
Chem. Biol., Vol. 12, (2005), pp. 121-129.


Y. Najajreh, D. Prilutski, Y. Ardeli-Tzaraf, J.-M. Perez, E. Khazanov, Y. Barenholz, J. Kasparkova, V. Brabec, D. Gibson:
Structure and unique interactions with DNA of a cationic trans-platinum complex with the nonplanar bicyclic piperidinopiperidine ligand,
Angew. Chem. Int. Ed., Vol. 44, (2005), pp. 2-4.


V. Brabec, J. Kasparkova:
Platinum-based drugs,
In: M. Gielen and E.R.T. Tiekink (Eds.): Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine,
John Wiley and Sons, Ltd, Chichester, 2005, pp. 489-506.


V. Bursova, J. Kasparkova, C. Hofr, V. Brabec:
Effects of monofunctional adducts of Platinum(II) complexes on thermodynamic stability and energetics of DNA duplexes,
Biophys. J., Vol. 88, (2005), pp. 1207-1214.


V. Brabec, J. Kasparkova:
DNA interactions of platinum anticancer drugs. Recent advances and mechanisms of action,
In: J.-M. Perez-Martin, M.A. Fuertes and C. Alonso (Eds.):
Metal Compounds in Cancer Chemotherapy,
Research Signpost, Trivandrum, Kerala (India), 2005, pp. 187-218.


V. Brabec, J. Kasparkova:
Modifications of DNA by platinum complexes: Relation to resistance of tumors to platinum antitumor drugs,
Drug Resist. Updates, Vol. 8, (2005), pp. 131-146.

V. Marini, P. Christofis, O. Novakova, J. Kasparkova, N. Farrell, V. Brabec:
Conformation, protein recognition and repair of DNA interstrand and intrastrand cross-links of antitumor trans-[PtCl2(NH3)(thiazole)],
Nucleic Acids Res., Vol. 33, (2005), pp. 5819-5828.

Y. Najajreh, J. Kasparkova, V. Marini, D. Gibson, V. Brabec:
Structural characterization and DNA interactions of new cytotoxic transplatin analogues containing one planar and one nonplanar heterocyclic amine ligand,
J. Biol. Inorg. Chem., Vol. 10, (2005), pp. 722-731.