Main

Fields of interest:

• molecular immunology
• antibody diversity

Recent publications:

Shinkura, R., Ito, S., Begum, N. A., Nagaoka, H., Muramatsu, M., Kinoshita, K., Sakakibara, Y., Hijikata, H. and Honjo, T.
Separate domains of AID are required for somatic hypermutation and class-switch　recombination.
Nature Immunol. 5 707-712 (2004)

Begum, N. A. and Honjo, T.
Response to comment on "Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch".
Science 306 2042c (2004)

Muramatsu, M., Nagaoka, H., Shinkura, R., Begum, N. A. and Honjo, T.
Discovery of activation-induced cytidine deaminase, the engraver of antibody memory.
Adv. Immunol. 94 1-36 (2007)

Shivarov, V., Shinkura, R. and Honjo, T.
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants.
Proc. Natl. Acad. Sci. USA. 105 15866-15871 (2008)

Begum, N.A., Stanlie, A., Doi, T., Sasaki, Y., Jin, H. W., Kim, Y.S., Nagaoka, H. and Honjo, T.
Further evidence for involvement of a non-canonical function of uracil DNAglycosylase in class switch recombination.
Proc. Natl. Acad. Sci. USA 106 2752-2757 (2009)

Doi, T., Kato, L., Ito, S., Shinkura, R., Wei, M., Nagaoka, H., Wang, J. and Honjo, T.
The C-terminal region of AID is responsible for a novel function other than DNA cleavage in class switch recombination.
Proc. Natl. Acad. Sci. USA 106 2758-2763 (2009)

Tsuji, M., Komatsu, N., Kawamoto, S., Suzuki, K., Kanagawa, O., Honjo, T., Hori, S and Fagarasan, S.
Preferential generation of follicular B helper T (TFH) cells from Foxp3+ T cells in gut Peyer's patches.
Science 323 1488-1493 (2009)

Tran, T., Nakata, M., Suzuki, K., Begum, N. A., Shinkura, R., Fagarasan, S., Honjo, T. and Nagaoka, H.
B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.
Nature Immunol. 11 148-154 (2010)