Main

Fields of interest:

• Ecology and evolution of influenza A viruses in southern China
• Identification of the emergency of animal influenza viruses with pandemic potential
• Ecology of SARS

Recent publications:

Kao, R. Y., D. Yang, L. S. Lau, W. H. W. Tsui, L. H. Hu, J. Dai, M. P. Chan, C. M. Chan, P. Wang, B. J. Zheng, J. A. Sun, J. D. Huang, J. Madar, G. H. Chen, H. L. Chen, Y. Guan, and K. Y. Yuen. 2010. Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol 28(6):600-5.

Vijaykrishna, D., L. L. M. Poon, H. C. Zhu, S. K. Ma, O. T. W. Li, C. L. Cheung, G. J. D. Smith, J. S. M. Peiris, and Y. Guan. 2010. Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine. Science 328(5985):1529.

Huang, K., J. Bahl, X. H. Fan, D. Vijaykrishna, C. L. Cheung, R. J. Webby, R. G. Webster, H. Chen, G. J. D. Smith, J. S. M. Peiris, and Y. Guan. 2010. Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China. J Virol 84(14):6978-86.

Tu, W. W., H. W. Mao, J. A. Zheng, Y. P. Liu, S. S. Chiu, G. Qin, P. L. Chan, K. T. Lam, J. Guan, L. J. Zhang, Y. Guan, K. Y. Yuen, J. S. M. Peiris, and Y. L. Lau. 2010. Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-React against 2009 Pandemic H1N1 Influenza Virus. J Virol 84(13):6527-35.

Zhang J, Zhang Z, Fan X, Liu Y, Wang J, Zheng Z, Chen R, Wang P, Song W, Chen H, Guan Y. 2010. 2009 pandemic H1N1 influenza virus replicates in human lung tissues. J Infect Dis 201(10):1522-6.

Zhu H, Wang J, Wang P, Song W, Zheng Z, Chen R, Guo K, Zhang T, Peiris JS, Chen H, Guan Y. 2010. Substitution of lysine at 627 position in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice. Virology 401(1):1-5.

Chen, Y. X., F. H. Xu, X. Gui, K. Y. Yang, X. R. Wu, Q. B. Zheng, S. X. Ge, Q. A. Yuan, A. E. T. Yeo, J. Zhang, Y. Guan, H. L. Chen, and N. S. Xia. 2010. A rapid test for the detection of influenza A virus including pandemic influenza A/H1N1 2009. J Virol Methods 167(1):100-2.

Chan MC, Chan RW, Yu WC, Ho CC, Yuen KM, Fong JH, Tang LL, Lai WW, Lo AC, Chui WH, Sihoe AD, Kwong DL, Wong DS, Tsao GS, Poon LL, Guan Y, Nicholls JM, Peiris JS. 2010. Tropism and Innate Host Responses of the 2009 Pandemic H1N1 Influenza Virus in ex Vivo and in Vitro Cultures of Human Conjunctiva and Respiratory Tract. Am J Pathol 176(4):1828-40.

Smith, G. J. D., and Y. Guan. 2010. Ecology and evolution of H5N1 in birds. Influenza and Other Respi Viruses 4:35.

Smith GJ, Vijaykrishna D, Bahl J, Lycett SJ, Worobey M, Pybus OG, Ma SK, Cheung CL, Raghwani J, Bhatt S, Peiris JS, Guan Y, Rambaut A. 2009. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 459:1122-5.