Main

Fields of interest:

• Experimental pharmacology - CNS acting drug; chemical structure-activity relationships; pharmacology of antiepileptic drugs; absence epilepsy models and involvement of GABA-ergic mechanisms of its action; GABAB receptor agonists and antagonists; behavioural and receptor autoradiography studies; drugs improving learning and memory processes; brain degenerative diseases - epilepsy and Alzheimer's disease
• Clinical Pharmacology - drug pharmakokinetic, drug monitoring of antiepileptic drugs, levels of excitatory amino acids as glutamate and aspartate in epileptic patients; Alzheimer's disease; pharmacoeconomic etc

Recent publications:

A. Krustev, D. Getova, V. Spassov, V. Turijski:
Effects of GABAB receptor antagonists on spontaneous and on GABA-induced mechanical activity of guinea- pig smooth muscle preparations,
Eur. Journal of Pharmacol., Vol. 431, (2001), pp. 339-344.

D. Getova, N.G. Bowery:
Effects of high affinity GABAB receptor antagonists on active and passive avoidance responding in rodents with gamma- hydroxybutyrolactone-induced absence epilepsy,
Psychopharmacology (Berlin), Vol. 157(1), (2001), pp. 89-95.

G. Minkova, D. Getova:
Determination of carbamazepine and its metabolite carbamazepine-10,11-epoxide in serum with gas-chromatography mass spectrometry,
Meth. Find. Exptl. Clin. Pharmacol., Vol. 23(9), (2001), pp. 481-485.

D. Getova, D. Dimitrova, J. Roukounakis:
Study of the effects of antidepressant drug moclobemide on learning and memory in rats,
Meth. Find. Exptl. Clin. Pharmacol, Vol. 25(10), (2003), pp. 811-815.

V. Turijski, A. Krustev, D. Getova-Spassova, V. Spassov:
Influence of Tacrine on Dopamine-induced reactions of the gastric smooth muscle of rats,
Meth. Find. Exptl. Clin. Pharmacol, Vol. 26(2), (2004), pp. 103-107.

V. Turiiski, A. Krustev, V. Sirakov, D. Getova:
In vivo and in vitro study of the influence of the anticholinesterase drug galantamine on motor and evacuative functions of rat gastrointestinal tract,
Eur. J. Pharmacol., Vol. 498(1-3), (2004) pp. 233-239.

D. Dimitrova, D. Getova:
Metrifonate - an irreversible cholinesterase inhibitor for treatment of Alzheimer disease,
Scientific Researches of the Union of Scientists - Plovdiv, Bulgaria, Series D. Medicine, Pharmacy and Stomatology, Medicine and Stomatology Session, Vol. 1, (2004), pp. 87-91.

D. Getova-Spassova:
The role of brain cholinesterases and their inhibition in treatment of Alzheimer's disease, East-Eurpoean Symposium "Central and peripheral synaptic transmission" October 5-9, 2005, Varna, Bulgaria.
In: Autonomic & Autocoid Pharmacology, Vol. 26, (2006), pp.50-51.

D. Dimitrova, D. Getova-Spassova:
Effects of galantamine and donepezil on active and passive avoidance tests in rats with induced hypoxia,
J. Pharmacol. Sci., Vol. 101, (2006), pp. 199-204.

A. Krustev, M.D. Argirova, D.P. Getova, V.I. Turiiski, N.A. Prissadova:
Calcium-independent tacrine-induced relaxation of rat gastric corpus smooth muscles,
Can J. Physiol. Pharmacol., Vol. 84(11), (2006), pp. 1133-1138.