Main

Fields of interest:

• Comparative genomics
• Metabolic reconstruction and functional annotation of genes and proteins
• Identification of regulatory signals
• Evolution of metabolic pathways and regulatory systems
• Alternative splicing
• Statistics of DNA sequences

Recent publications:

A.G. Vitreschak, A.A. Mironov, V.A. Lyubetsky and M.S.Gelfand:
Functional and evolutionary analysis of the T-box regulon in bacteria,
RNA, (2008), (in press)

D.A. Rodionov and M.S. Gelfand:
Comparative genomics and functional annotation of bacterial transporters,
Physics of Life Reviews, (2008), in press

G. Kolesov, Z. Wunderlich, O.N. Laikova, M.S. Gelfand and L.A. Mirny:
How gene order is influenced by the biophysics of transcription regulation,
Proc. Natl. Acad. Sci. USA, Vol. 104, (2007), pp. 13948-13953.

I.I. Artamonova and M.S.Gelfand:
Comparative genomics and evolution of alternative splicing: the pessimists' science,
Chem. Rev., Vol. 107, (2007), pp. 3407-3430.

V. Spirin, M.S. Gelfand, A.A. Mironov and L.A. Mirny:
A metabolic network in the evolutionary context: Multiscale structure and modularity,
Proc. Natl. Acad. Sci. USA, Vol. 103, (2006), pp. 8774-8779.

M.S. Gelfand:
Evolution of transcriptional regulatory networks in microbial genomes,
Curr. Opin. Struct. Biol., Vol. 16, (2006), pp. 420-429.

D.B. Malko, V.J. Makeev, A.A. Mironov and M.S. Gelfand:
Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes,
Genome Res., Vol. 16, (2006), pp. 505-509.

D.A. Rodionov, I.L. Dubchak, A.P. Arkin, E.J. Alm and M.S. Gelfand:
Dissimilatory metabolism of nitrogen oxides in bacteria: comparative reconstruction of transcriptional networks,
PLoS Comput. Biol., Vol. 1, (2005), e55.

D.A. Rodionov and M.S. Gelfand:
Identification of a bacterial regulatory system for ribonucleotide reductases
by phylogenetic profiling,
Trends Genet., Vol. 21, (2005), pp. 385-389.

J.P. Fededa, E. Petrillo, M.S. Gelfand, A.D. Neverov, S. Kadener, G. Nogues, F. Pelisch, F.E. Baralle, A.F. Muro and A.R. Kornblihtt:
A polar mechanism coordinates different regions of alternative splicing within a single gene,
Mol. Cell., Vol.19, (2005), pp. 393-404.