Main

Fields of interest:

• Biophysics
• Peptide chemistry
• Protein-protein interactions
• Chemical chaperones
• Cancer
• HIV

Recent publications:

S. Rotem, C. Katz and A. Friedler:
Insights into the structure and protein-protein interactions of the pro-apoptotic protein ASPP2,
Biochem. Soc. Transac., (2007), in press.

Z. Hayouka, J. Rosenbluh, A. Levin, S. Loya, M. Lebendiker, D.B. Veprintsev, M. Kotler, A. Hizi, A. Loyter and A. Friedler:
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium,
PNAS, Vol. 104(20), (2007), pp. 8316-8321.

O. Karni-Schmidt, A. Friedler, A. Zupnick, K. McKinney, M. Mattia, R. Beckerman, P. Bouvet, M. Sheetz, A. Fersht and C. Prives:
Energy dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carboxyl terminus,
Oncogene, Vol. 26(26), (2007), pp. 3878-3891.

J. Rosenbluh, Z. Hayouka, S. Loya, A. Levin, A. Armon-Omer, L. Britan, A. Hizi, M. Kotler, A. Friedler and A. Loyter:
Interaction between the HIV-1 Rev and IN proteins: a base for the development of anti-HIV peptides,
J. Biol. Chem., Vol. 282(21), (2007), pp. 15743-15753.

S. Diamant, E. Podoly, A. Friedler, H. Ligumsky, O. Livnah and H. Soreq:
Butyrylcholinesterase attenuates amyloid fibril formation in vitro,
Proc. Natl. Acad. Sci. USA., Vol. 103(23), (2006), pp. 8628-8633.

A. Friedler, D.B. Veprintsev, S.M.V. Freund, K.I. von Glos and A.R. Fersht:
Modulation of binding of DNA to the C-terminal domain of p53 by acetylation,
Structure, Vol. 13(4), (2005), pp. 629-636

A. Friedler, D.B. Veprintsev, T. Rutherford, K.I. von Glos and A.R. Fersht:
Binding of Rad51 and other peptide sequences to a promiscuous, highly electrostatic, binding site in p53,
J. Biol. Chem., Vol. 280, (2005), pp. 8051-8059.

A. Friedler, B.S. DeDecker, S.M.V. Freund, C. Blair, S. Rüdiger and A.R. Fersht:
Structural destabilisation of p53 by the R249S mutation, and its rescue by a designed peptide: implications for the "mutant conformation" ,
J. Mol. Biol., Vol. 336, (2004), pp. 187-196.

N. Issaeva, A. Friedler, P. Bozko, K.G. Wiman, A.R. Fersht and G. Selivanova:
Rescue of mutants of the tumour suppressor p53 in cancer cells by a designed peptide,
Proc. Natl. Acad. Sci. USA, Vol. 100, (2003), pp. 13303-13307.

A. Friedler, D.B. Veprintsev, L.O. Hansson and A.R. Fersht:
Kinetic instability of p53 core domain mutants: implications for rescue by small molecules,
J. Biol. Chem., Vol. 278, (2003), pp. 24108-24112.

A. Friedler, L.O. Hansson, D.B. Veprintsev, S.M.V. Freund, T.M. Rippin, P.V. Nikolova, M.R. Proctor, S. Rüdiger and A.R. Fersht:
A peptide that binds and stabilises p53 core domain: chaperone strategy for rescue of oncogenic mutants,
Proc. Natl. Acad. Sci. USA, Vol. 99, (2002), pp. 937-942.