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Fields of interest:

Cell biology with particular focus on cancer cell growth and the regulatory mechanisms associated with cell proliferation, apoptosis and sensitivity to anti-tumor drugs.

Recent publications:

M.L. Heuze, F.C. Guibal, C.A. Banks, X. Huang, Z. Darzynkiewicz, J.W. Conaway,
R.C. Conaway, Y.E. Cayre, P.G. Lutz:
A mutated ASB2 which can no longer assemble in an E3 ubiquitin ligase complex, induces apoptosis in RA-treated leukemia cells,
EMBO J. (submitted)

H.-S. Huang, P. Pozarowski, Z. Darzynkiewicz, G. Yan, E.Y.C. Lee:
Protein accumulation in the nucleolus: a search for nucleolar targeting signal and nuclear localization signal in protein phosphatase-1 inhibitor-3,
J. Biol Chem., (submitted)

H.D. Halicka, X. Huang, F. Traganos, M.A. King, W. Dai, Z. Darzynkiewicz:
Histone H2AX phosphorylation after cell irradiation with UV-B: Relationship to cell cycle phase and induction of apoptosis,
Cell Cycle (in press).

J . Chen, J. Eskander, X. Huang, D. Halicka, Z. Darzynkiewicz, M.S. Goligorsky:
Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53,
J. Cell Biol. (submitted).

S.R. Gupte, P. Pozarowski, J. Grabarek, F. Traganos, Z. Darzynkiewicz,
M.Y.W.T. Lee:
RIa influences cell proliferation by transporting RFC40 into the nucleus,
Cancer Res. (submitted).