Main

Fields of interest:

• Human normal and leukaemic stem cells
• Mesenchymal stroma cells
• Stem cell niche
• Self-renewal and cell fate control of stem cells

Recent publications:

E. Siapati, B.W. Bigger, K. Kashofer, M. Themis, A.J. Thrasher and D. Bonnet:
Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells.
Eur. J. Hematol., Vol. 78, (2007), pp. 303-­313.

D. Pearce and D. Bonnet:
The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells.
Exp. Hematol., Vol. 35, (2007), pp. 1437-1446.

F. Anjos-Afonso and D. Bonnet:
Non-hematopoietic/endothelial SSEA-1pos cells defines the most primitive progenitors in the adult murine bone marrow mesenchymal compartment,
Blood, Vol. 109, (2007), pp. 1298-1306.

D. Pearce, F. Anjos-Afonso, C.M. Ridler, A. Eddaoudi and D. Bonnet:
Age dependent increase in SP distribution within Hematopoiesis: implications for our understanding of the mechanism of aging,
Stem Cells., Vol. 25, (2007), pp. 828-835.

S. Aguilar, Nyee, J. Chan, M. Loebinger, B. Spencer-Dene, N. Fisk, G. Stamp, S.M. Janes and D. Bonnet:
Murine but not Human Mesenchymal Stem Cells Generate Osteosarcoma-Like Lesions in the Lung,
Stem Cells, (2007), Mar 15; [Epub ahead of print] PMID: 17363552.

D.J. Pearce, D. Taussig, K. Zibara, L.L. Smith, C.M. Ridler, C. Preudhomme, B.D. Young, A.Z. Rohatiner, T.A. Lister and D. Bonnet:
AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML,
Blood, Vol. 107, (2006), pp. 1166-1179.

J. Rangatia and D. Bonnet:
Lentiviral silencing of BCR-ABL alone induces apoptosis, cell cycle and proliferation arrest and differentiation,
Leukemia, Vol. 20, (2006), pp. 68-76.

E.K. Siapati, B.W. Bigger, J. Miskin, D. Chipchase, K.L. Parsley, K. Mitrophanous, M. Themis, A.J. Thrasher and D. Bonnet:
Comparison of HIV- and EIAV-based vectors on their efficiency to transduce murine and human hematopoietic stem cells,
Mol. Ther., Vol. 12, (2005), pp. 537-546.

D.J. Pearce, D. Taussig, C. Simpsom, K. Allen, A.Z. Rohatimer, T.A. Lister and D. Bonnet:
Characterization of cells with a high Aldehyde Dehydrogenase (ALDH) activity in cord blood and AML samples,
Stem Cells, Vol. 23, (2005), pp. 752-760.

D. Taussig, D. Pearce, C. Simpson, A.Z. Rohatiner, T.A. Lister, G. Kelly, J.L. Luongo, G.H. Dannet, D. Bonnet:
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia,
Blood, Vol. 106, (2005), pp. 4086-4092.